Dysplastic nevus - Displastik Nevus
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Dysplastic nevi ― G'arbliklarga biopsiya tavsiya etiladi.
References
Dysplastic nevus , shuningdek, atipik yoki Klarks nevusu sifatida ham tanilgan, dermatologiya va dermatopatologiyada munozaralarni keltirib chiqardi. Shifokorlar ko'pincha bu mollarni biopsiya qilishadi, chunki ular g'ayritabiiy ko'rinishi va melanoma haqida tashvishlanishlari mumkin.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , shuningdek, atipik yoki Klark nevuslari sifatida ham tanilgan, ba'zida melanomaga olib kelishi mumkin. Melanomalarning taxminan 36% displastik nevuslar yaqinida joylashgan. Displastik nevus melanomaga aylanishi mumkin bo'lgan belgilar notekis shakl, ko'proq pigment o'zgarishi yoki kulrang rangni o'z ichiga oladi. Ushbu saratonlar odatda yoshroq (30-yillarning o'rtalarida) sodir bo'ladi, ko'p bo'lishi mumkin va ko'pincha magistralda bo'ladi. Genetik jihatdan, dysplastic nevi yaxshi nevus va melanoma o'rtasida joylashgan. Ammo, melanomalarning atigi 20% dan 30% gacha mavjud nevuslardan kelib chiqadi. Aksariyat nevuslar melanomaga aylanmagani uchun ularni profilaktika maqsadida olib tashlash tavsiya etilmaydi.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma - teri rangi uchun mas'ul bo'lgan melanotsitlar saratonga aylanganda paydo bo'ladigan o'sma turi. Melanotsitlar nerv tepasidan kelib chiqadi. Bu shuni anglatadiki, melanomalar nafaqat terida, balki oshqozon-ichak trakti va miya kabi asab hujayralari ko'chib yuradigan boshqa joylarda ham rivojlanishi mumkin. Erta bosqichdagi melanoma (0-bosqich) bilan og'rigan bemorlarning omon qolish darajasi yuqori bo'lib, 97% ni tashkil qiladi, bu esa ilg'or bosqichli kasallik tashxisi qo'yilganlarda (IV bosqich) taxminan 10% gacha kamayadi.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Saraton xavfi
Qo'shma Shtatlardagi kavkazlik odamlarda ko'rinib turganidek, displastik nevuslari bo'lganlar umr bo'yi melanoma rivojlanish xavfi 10% dan yuqori. Boshqa tomondan, displastik nevus bo'lmaganlarda melanoma rivojlanish xavfi 1% dan kam.
○ Displastik nevuslari bo'lgan shaxslar uchun ehtiyot choralari
Terini o'z-o'zini tekshirish odatda melanomaning oldini olish (olib tashlash mumkin bo'lgan atipik nevuslarni aniqlash orqali) yoki mavjud o'smalarni erta aniqlash uchun tavsiya etiladi. Shaxsiy yoki oilaviy tarixda teri saratoni yoki bir nechta atipik nevuslari bo'lgan odamlar melanoma rivojlanmaganligiga ishonch hosil qilish uchun yiliga kamida bir marta dermatologga murojaat qilishlari kerak.
[ABCDE] qisqartmasi tibbiyot xodimlari va oddiy odamlarga melanomaning asosiy xususiyatlarini eslab qolishlariga yordam berish uchun foydali bo'lgan. Afsuski, oddiy odam uchun ko'plab seboreik keratozlar, ba'zi lentigo senilis va hatto siğil [ABCDE] xususiyatlariga ega bo'lishi mumkin va ularni melanomadan ajratib bo'lmaydi.
○ [ABCDE]
Asymmetrical: Terining assimetrik shikastlanishi.
Border: Shikastlanish chegarasi tartibsiz.
Color: melanomalar odatda bir nechta tartibsiz ranglarga ega.
Diameter: 6 mm dan katta nevuslar kichikroq nevuslarga qaraganda melanoma bo'lish ehtimoli ko'proq.
Evolution: Nevus yoki lezyonning evolyutsiyasi (ya'ni o'zgarishi) lezyonning malign bo'lib qolganligini ko'rsatishi mumkin.